Molecular group:
Immune cells
Molecule/Cell:
CD1d-restricted NKT cells
Plasmodium strain:
Plasmodium berghei NK65
pRBC infection titer:
10^6
Mouse genetic background (Con):
129/Sv x C57BL/6
Level of backcrossing:
Mixed background (50%)
Experimental treatment group (EG):
CD1d -/-
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
Liver pathology
Pathology (EG):
Liver pathology
Parasitemia (EG vs Con):
N.I.
Additional phenotypes (EG vs Con):
Similar serum GPT (ALT) and liver injury
Refs:
Adachi et al., 2001, J Immunol
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