Molecular group:
Immune cells
Molecule/Cell:
CD4+CD25+Foxp3+ Treg cells
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^6
Mouse genetic background (Con):
BALB/c
Experimental treatment group (EG):
anti-CD25 (day -2 and -6h)
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
No CM
Pathology (EG):
CM (20%)
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
↑ splenic CD4+ T cell proliferation and IL-2 production; ↑ parasite-specific T cell proliferation; similar IL-4 and ↑ IFN-g production by splenic T cells; when challenged with a secondary infection, parasitemia was decreased and mortality by CM increased (up to 80 %)
Refs:
Nie et al., 2007, Infect Immun
Hyperlink: