Molecular group:
Immune cells
Molecule/Cell:
CD4
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^6
Mouse genetic background (Con):
CBA/Ca, CBA/J
Experimental treatment group (EG):
CD4+ T cells from mice with CM (LN derived)
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM (100%)
Pathology (EG):
CM (100%)
Parasitemia (EG vs Con):
N.I.
Additional phenotypes (EG vs Con):
More severe brain hemorrhages and earlier mortality when mice received CD4+ T cells from mice dying of CM than from normal mice
Refs:
Grau et al., 1986, J Immunol
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