Molecular group:
Leucocyte effector mechanisms and proteases
Molecule/Cell:
caspases
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
♂ 5 x 10^5
Mouse genetic background (Con):
C57BL/6
Experimental treatment group (EG):
caspase inhibitor (ZVAD-fmk)
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM (100%)
Pathology (EG):
CM (100%)
Parasitemia (EG vs Con):
N.I.
Additional phenotypes (EG vs Con):
The inhibitor does not cross the BBB, making it difficult to prevent neuronal apoptosis
Refs:
Helmers et al., 2008, Am J Trop Med Hyg
Hyperlink: