Molecular group:
Signal transduction and intracellular danger sensors
Molecule/Cell:
Bcl-2
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
♀ 10^6, ♂ 5 x 10^5
Mouse genetic background (Con):
C57BL/6
Experimental treatment group (EG):
over-expression of bcl-2 in myeloid cells (hMRP8-Bcl-2 mice)
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM (100%)
Pathology (EG):
CM (100%)
Parasitemia (EG vs Con):
N.I.
Additional phenotypes (EG vs Con):
Similar number of TUNEL-positive cells in the brain
Refs:
Helmers et al., 2008, Am J Trop Med Hyg
Hyperlink: