Molecular group:
Leucocyte effector mechanisms and proteases
Molecule/Cell:
Caspase-12
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^2 - 10^3
Mouse genetic background (Con):
C57BL/6
Level of backcrossing:
Backcrossed for 9 generations
Experimental treatment group (EG):
Casp12 -/-
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM (55%)
Pathology (EG):
CM (90%)
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
↑ serum IL-1b 10 days p.i.; ↑ mRNA expression of TNF-a, IL-6, MCP-1 and MIP-1 in the brain 10 days p.i.
Refs:
Labbé et al., 2010, J Immunol
Hyperlink: