Molecular group:
Leucocyte effector mechanisms and proteases
Molecule/Cell:
Caspase-1
Plasmodium strain:
Plasmodium chabaudi AS
pRBC infection titer:
10^6
Mouse genetic background (Con):
C57BL/6 x 129/S2SvPas
Level of backcrossing:
N.I.
Experimental treatment group (EG):
Casp1 -/-
Lethal infection (Con):
no
Lethal infection (EG):
no
Pathology (Con):
N.I.
Pathology (EG):
N.I.
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
Similar serum IFN-g, TNF-a, IL-10; similar serum IgG1 and IgG2a 21 days p.i.; ↓ serum IL-18 6-7 days p.i.; similar anemia and weight loss; similar production of IFN-g, IL-10 and IL-1b by splenocytes after stimulation with pRBCs
Refs:
Labbé et al., 2010, J Immunol
Hyperlink: