Molecular group:
Leucocyte effector mechanisms and proteases
Molecule/Cell:
Caspase-1
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^6
Mouse genetic background (Con):
N.I.
Level of backcrossing:
N.I.
Experimental treatment group (EG):
Caspase-1 -/-
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM (100%)
Pathology (EG):
CM (100%)
Parasitemia (EG vs Con):
N.I.
Additional phenotypes (EG vs Con):
N.I.
Refs:
Reimer et al., 2010, Eur J Immunol
Hyperlink: