Molecular group:
Adhesion molecules
Molecule/Cell:
CD36
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
♂ 5 x 10^5; ♀ 10^6
Mouse genetic background (Con):
C57BL/6
Level of backcrossing:
Backcrossed for 4 generations
Experimental treatment group (EG):
CD36 -/-
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
ALI, CM (100%)
Pathology (EG):
↓ ALI, CM (100%)
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
↓ lung pathology: ↓ IgM in bronchoalveolar lavage fluid
Refs:
Lovegrove et al., 2008, PLoS Pathog
Hyperlink: