Molecular group:
Adhesion molecules
Molecule/Cell:
CD36
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^5 - 10^6
Mouse genetic background (Con):
C57BL/6 x 129/Sv
Level of backcrossing:
Backcrossed for 4 generations
Experimental treatment group (EG):
CD36 -/-
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM (100%)
Pathology (EG):
CM (100%)
Parasitemia (EG vs Con):
Slightly decreased
Additional phenotypes (EG vs Con):
Similar neurologic symptoms; ↓ schizont sequestration in adipose and lung tissue; no schizont sequestration in brain (similar to WT); ↑ parasite accumulation in spleen (↑ pRBC clearance?); ↑ number of schizonts in peripheral blood
Refs:
Franke-Fayard et al., 2005, Proc Natl Acad Sci U S A
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