Molecular group:
Adhesion molecules
Molecule/Cell:
CD11a/CD18 (LFA-1)
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^6
Mouse genetic background (Con):
CBA/Ca
Experimental treatment group (EG):
anti-CD11a
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM (85-90%)
Pathology (EG):
N.I.
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
Prolonged survival (2-3 weeks: late as well as early treatment); no neurological symptoms; no vascular permeability in brain and ↓vascular permeability in lungs; ↓ mononuclear cell sequestration in brain and lungs; ↓ (brain) and similar (lungs) platelet accumulation; similar microhemorrhages in the brain; ↓ myeloperoxidase activity (neutrophil enzyme) in lungs; similar liver pathology; ↓injected aggregated albumin localization in brain and lungs
Refs:
Senaldi et al., 1994, Infect Immun
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