Molecular group:
Adhesion molecules
Molecule/Cell:
CD11a/CD18 (LFA-1)
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^6
Mouse genetic background (Con):
CBA/Ca
Experimental treatment group (EG):
anti-CD11a
Lethal infection (Con):
yes
Lethal infection (EG):
70% (at the end of observation week 4)
Pathology (Con):
CM (85%)
Pathology (EG):
CM (10%)
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
Prolonged survival (2-3 weeks: late as well as early treatment, no effect if administered when symptoms are evident); no neurological symptoms; ↓ serum TNF-a; similar mononuclear cell sequestration in the brain
Refs:
Grau et al., 1991, Eur J Immunol
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