Molecular group:
Adhesion molecules
Molecule/Cell:
CD11a/CD18 (LFA-1)
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^6
Mouse genetic background (Con):
CBA/Ca
Experimental treatment group (EG):
anti-CD11a
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM (100%)
Pathology (EG):
CM (i.v.0%; i.p.30%)
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
Prolonged survival (2-3 weeks: late as well as early treatment, no effect if administered when symptoms were evident); no neurological symptoms; ↑ protection when administered i.v. compared to i.p.; similar mononuclear cell sequestration in the brain (WT: sequestering cells are almost all monocytes or mononuclear phagocytes, only very few T, B cells or neutrophils were observed)
Refs:
Falanga et al., 1991, Eur J Immunol
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